The smart Trick of ceesdekker.net That Nobody is Discussing
The smart Trick of ceesdekker.net That Nobody is Discussing
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2009, discovery of a completely new phenotype for micro organism in narrow nanofluidic slits; and very first detection of regional protein constructions alongside DNA employing stable-point out nanopores
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Dynamics of initiation, termination and reinitiation of DNA translocation with the motor protein EcoR124I
Our operate was promptly adopted up by Some others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their conclusions on transistors comprised of one- and multi-walled carbon nanotubes in Used Physics Letters.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with at any time research of the dynamics DNA supercoils and the discovery of supercoil hopping
Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
You are a Christian. If you could possibly make such a artificial cell, would you be a person phase closer to God, or would the position of God have diminished relatively all over again?
He also found time to put in writing several textbooks, send Practically forty thousand tweets and guide a successful exploration group at Delft University of Technological know-how. ‘It doesn’t truly feel like get the job done’, he says. ‘I’m just terribly curious.’
Imagine if, as opposed to using typical leading-down silicon electronics, transistors can be created from The underside up employing one natural molecules given that the switching aspects? This concept, which grew to become The premise of these days’s subject of molecular electronics, initial emerged during the 1970s.
1). The existing–voltage curves showed major modulations with gate voltage, even at space temperature, which was according to band bending within a ~0.six eV bandgap semiconducting nanotube. These information also confirmed which the conductance may be modulated by 6 orders of magnitude by modifying the gate voltage. The results of this work — a space-temperature transistor comprised of just one carbon nanotube molecule — ended up published in Character in May well 1998.
Because 2000 he moved to one-molecule biophysics and nanobiology, with analysis from studies of DNA loop extrusion and supercoiling to DNA translocation by nanopores. Much more recently his investigation has focused on finding out chromatin structure and cell division with germs on chip, when he is additionally seeking to in the end Establish synthetic cells from The underside up.
Cees Dekker is Distinguished University Professor at TU Delft. Educated as a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes from the nineties. Given that 2000, he moved to single-molecule biophysics and nanobiology. His present-day exploration focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, specifically SMC motor protein; and (iii) creating a living artificial cell from lifeless molecules. Dekker can be an elected member with the KNAW and fellow for the APS and also the IOP.
Enable’s initially look back in the intervening time if you made a decision to change your focus from superconductivity and nanotubes to biology at the end of the 1990s.
Strong-state nanopores have proven to generally be a shockingly functional probe for solitary-molecule Evaluation of cees dekker DNA. I will explain a number of our latest findings – specifically DNA knots – and our initiatives to increase the capabilities of good-point out nanopores even even more, within the direction of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.